Aging · 2019
D-ribose is elevated in T1DM patients and can be involved in the onset of encephalopathy.
СтатьяПоддержка исследования: вне правительства СШАНазвание и аннотация: Перевод пока не подготовлен
Обработка статьи · этапы, ошибки и управление
Загрузка состояния…
Ошибки и ограничения
История · было → стало
Состояние обновляется каждые 5 секунд, пока блок открыт. Процент показывается только там, где известен объём работы. Пауза останавливает продолжение этапа; текущий запрос к источнику может завершиться.
Yu Lexiang, Chen Yao, Xu Yong, He Tao, Wei Yan, He Rongqiao
Аннотация
BACKGROUND: Diuretics are a common intervention in critically ill patients with acute kidney injury (AKI). However, there is no information that describes the practice patterns of diuretic use by clinicians.
METHODS: Multinational, multicenter survey of intensive care and nephrology clinicians that utilized an 18-question self-reported questionnaire.
RESULTS: The survey generated 331 responses from 16 countries. Academic institutions comprised 77.5%, with the remaining being from metropolitan, regional or private hospitals. The use of furosemide was most common (67.1%), delivered primarily intravenously (71.9%) and by bolus dosing (43.3%). Other diuretics were infrequently used. The majority rated current serum creatinine (73.6%) and urine output (73.4%), blood pressure (59.7%), central venous pressure (65.2%) and risk of toxicity (62.4%) important when deciding on a dose. Pulmonary edema was a prime physiologic indication for diuretic use (86.3%). Diuretic use was also common with rhabdomyolysis (55.6%), major surgery (56%), and cardiogenic shock (56.2%), and sepsis (49.5%). Diuretic use was most commonly given either prior to (57.7%) or during recovery (33.9%) after renal replacement therapy (RRT). Most (76.6%) targeted a diuresis of >or=0.5-1.0 ml/kg/h. The majority did not believe that diuretics could reduce mortality (74.3%), reduce need for (50.8%) or duration of RRT (57.8%) or improve renal recovery (68.2%), however, many stated uncertainty. Most (85.1%) would be willing to participate in a randomized trial (RCT) of diuretics in AKI with 72.4% believing it ethically acceptable to allocate patients to placebo.
CONCLUSION: Diuretics are frequently used in AKI. Clinicians are most familiar with furosemide given intravenously and titrated to a physiologic endpoint of urine output. Most clinicians believe an RCT on diuretic use in AKI is justified and ethical. This survey confirms clinical agreement and a need for higher quality evidence on diuretic use in AKI.
METHODS: Multinational, multicenter survey of intensive care and nephrology clinicians that utilized an 18-question self-reported questionnaire.
RESULTS: The survey generated 331 responses from 16 countries. Academic institutions comprised 77.5%, with the remaining being from metropolitan, regional or private hospitals. The use of furosemide was most common (67.1%), delivered primarily intravenously (71.9%) and by bolus dosing (43.3%). Other diuretics were infrequently used. The majority rated current serum creatinine (73.6%) and urine output (73.4%), blood pressure (59.7%), central venous pressure (65.2%) and risk of toxicity (62.4%) important when deciding on a dose. Pulmonary edema was a prime physiologic indication for diuretic use (86.3%). Diuretic use was also common with rhabdomyolysis (55.6%), major surgery (56%), and cardiogenic shock (56.2%), and sepsis (49.5%). Diuretic use was most commonly given either prior to (57.7%) or during recovery (33.9%) after renal replacement therapy (RRT). Most (76.6%) targeted a diuresis of >or=0.5-1.0 ml/kg/h. The majority did not believe that diuretics could reduce mortality (74.3%), reduce need for (50.8%) or duration of RRT (57.8%) or improve renal recovery (68.2%), however, many stated uncertainty. Most (85.1%) would be willing to participate in a randomized trial (RCT) of diuretics in AKI with 72.4% believing it ethically acceptable to allocate patients to placebo.
CONCLUSION: Diuretics are frequently used in AKI. Clinicians are most familiar with furosemide given intravenously and titrated to a physiologic endpoint of urine output. Most clinicians believe an RCT on diuretic use in AKI is justified and ethical. This survey confirms clinical agreement and a need for higher quality evidence on diuretic use in AKI.