Journal of neurovirology · 2001
Infections of the central nervous system of suspected viral origin: a collaborative study from Finland.
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Koskiniemi M, Rantalaiho T, Piiparinen H, von Bonsdorff C H, Färkkilä M, Järvinen A, Kinnunen E, Koskiniemi S, Mannonen L, Muttilainen M, Linnavuori K, Porras J, Puolakkainen M, Räihä K, Salonen E M, Ukkonen P, Vaheri A, Valtonen V, Study Group
Аннотация
We studied 3231 patients with acute central nervous system (CNS) symptoms of suspected viral origin to elucidate the current etiologic spectrum. In 46% of the cases, a viral finding was observed. Varicella-zoster virus (VZV) was the main agent associated with encephalitis, as well as meningitis and myelitis. VZV comprised 29% of all confirmed or probable etiologic agents. Herpes simplex virus (HSV) and enteroviruses accounted 11% each, and influenza A virus 7%. VZV seems to have achieved a major role in viral infections of CNS. In encephalitis in our population, VZV is clearly more commonly associated with these neurological diseases than HSV. The increase in VZV findings may in part be a pseudophenomenon due to improved diagnostic methods, however, a true increase may have occurred and the pathogenetic mechanisms behind this should be elucidated.
Предметные рубрики MeSH
Adenoviridae InfectionsAdolescentAdultAge DistributionAgedChildChild, PreschoolChlamydia InfectionsChlamydophila pneumoniaeEncephalitisEncephalitis, Herpes SimplexEncephalitis, Tick-BorneEncephalitis, Varicella ZosterEncephalitis, ViralEnterovirus InfectionsFemaleFinlandHerpesviridae InfectionsHumansImmunoenzyme TechniquesIncidenceInfantInfant, NewbornMaleMeningitisMiddle AgedMyelitisPolymerase Chain ReactionPuumala virusRetrospective StudiesRotavirus InfectionsSeroepidemiologic StudiesVaccinationViral Vaccines