[Synergism of ciprofloxacin with beta-lactam antibiotics, gentamicin, minocycline and pipemidic acid].

Studies on the Synergism of Ciprofloxacin with beta-Lactam Antibiotics, Gentamicin, Minocycline and Pipemidic Acid. Using Escherichia coli, Klebsiella pneumoniae/Klebsiella oxytoca, Pseudomonas aeruginosa and Staphylococcus aureus strains, we examined a possible influence of pipemidic acid, minocycline, gentamicin, cefazolin, mezlocillin and ampicillin on the antibiotic activity of ciprofloxacin. We found in all bacterial species synergistic influence by pipemidic acid. When ciprofloxacin was combined with gentamicin, synergism was observed in E. coli and in K. pneumoniae/oxytoca, additive effects in P. aeruginosa and S. aureus. In combination with minocycline we demonstrated synergism in S. aureus only. In all other bacterial species and antibiotic combinations we found neither synergism nor antagonism.