Indian pediatrics · 2014
Efficacy of levamisole in children with frequently relapsing and steroid-dependent nephrotic syndrome.
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Ekambaram Sudha, Mahalingam Vijayakumar, Nageswaran Prahlad, Udani Amish, Geminiganesan Sangeetha, Priyadarshini Shweta
Аннотация
OBJECTIVE: To assess the efficacy of levamisole in frequently relapsing nephrotic syndrome and steroid-dependent nephrotic syndrome.
STUDY DESIGN: Retrospective analysis of hospital case records.
SETTING: Pediatric nephrology department of a tertiary referral pediatric hospital.
PARTICIPANTS: 62 children with frequently relapsing nephrotic syndrome and 35 children with steroid-dependent nephrotic syndrome.
METHODS: Case records of children who were diagnosed as steroid-dependant or frequently-relapsing nephrotic syndrome from June 2004 to June 2011, were reviewed. Levamisole was given daily (2 mg/kg/d) along with tapering doses of alternate day steroids after remission on daily steroids.
RESULTS: Levamisole was effective in 77.3% children with a better (80.6%) efficacy in frequently relapsing nephrotic syndrome. A total of 34 children completed 1 year follow-up post levamisole therapy. The cumulative mean (SD) steroid dose 1-year before therapy was 4109(1154) mg/m2 and 1-year post therapy was 661 (11) mg/m2 (P<0.001). The relapses were also less during the period of post-levamisole therapy.
CONCLUSION: Levamisole is an effective alternative therapy in frequently relapsing and steroid-dependent nephrotic syndrome.
STUDY DESIGN: Retrospective analysis of hospital case records.
SETTING: Pediatric nephrology department of a tertiary referral pediatric hospital.
PARTICIPANTS: 62 children with frequently relapsing nephrotic syndrome and 35 children with steroid-dependent nephrotic syndrome.
METHODS: Case records of children who were diagnosed as steroid-dependant or frequently-relapsing nephrotic syndrome from June 2004 to June 2011, were reviewed. Levamisole was given daily (2 mg/kg/d) along with tapering doses of alternate day steroids after remission on daily steroids.
RESULTS: Levamisole was effective in 77.3% children with a better (80.6%) efficacy in frequently relapsing nephrotic syndrome. A total of 34 children completed 1 year follow-up post levamisole therapy. The cumulative mean (SD) steroid dose 1-year before therapy was 4109(1154) mg/m2 and 1-year post therapy was 661 (11) mg/m2 (P<0.001). The relapses were also less during the period of post-levamisole therapy.
CONCLUSION: Levamisole is an effective alternative therapy in frequently relapsing and steroid-dependent nephrotic syndrome.