Reproductive factors and exogenous hormone use in relation to risk of glioma and meningioma in a large European cohort study.
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Michaud Dominique S, Gallo Valentina, Schlehofer Brigitte, Tjønneland Anne, Olsen Anja, Overvad Kim, Dahm Christina C, Kaaks Rudolf, Lukanova Annekatrin, Boeing Heiner, Schütze Madlen, Trichopoulou Antonia, Bamia Christina, Kyrozis Andreas, Sacerdote Carlotta, Agnoli Claudia, Palli Domenico, Tumino Rosario, Mattiello Amalia, Bueno-de-Mesquita H Bas, Ros Martine M, Peeters Petra H M, van Gils Carla H, Lund Eiliv, Bakken Kjersti, Gram Inger T, Barricarte Aurelio, Navarro Carmen, Dorronsoro Miren, Sánchez Maria José, Rodríguez Laudina, Duell Eric J, Hallmans Göran, Melin Beatrice S, Manjer Jonas, Borgquist Signe, Khaw Kay-Tee, Wareham Nick, Allen Naomi E, Tsilidis Konstantinos K, Romieu Isabelle, Rinaldi Sabina, Vineis Paolo, Riboli Elio
Аннотация
METHODS: After a mean of 8.4 years of follow-up, 193 glioma and 194 meningioma cases were identified among 276,212 women. Information on reproductive factors and hormone use was collected at baseline. Cox proportional hazard regression was used to determine hazard ratios (HR) and 95% confidence intervals (95% CI).
RESULTS: No associations were observed between glioma or meningioma risk and reproductive factors, including age at menarche, parity, age at first birth, menopausal status, and age at menopause. A higher risk of meningioma was observed among postmenopausal women who were current users of hormone replacement therapy (HR, 1.79; 95% CI, 1.18-2.71) compared with never users. Similarly, current users of oral contraceptives were at higher risk of meningioma than never users (HR, 3.61; 95% CI, 1.75-7.46).
CONCLUSION: Our results do not support a role for estrogens and glioma risk. Use of exogenous hormones, especially current use, seems to increase meningioma risk. However, these findings could be due to diagnostic bias and require confirmation.
IMPACT: Elucidating the role of hormones in brain tumor development has important implications and needs to be further examined using biological measurements.