Clinical oncology (Royal College of Radiologists (Great Britain)) · 2026
Breast Cancer Adjuvant Radiotherapy Without Tattoos: Comparison Between Surface Imaging and Four-point Localisation.
СтатьяСравнительное исследованиеНазвание и аннотация: Перевод в очереди
Обработка статьи · этапы, ошибки и управление
Загрузка состояния…
Ошибки и ограничения
История · было → стало
Состояние обновляется каждые 5 секунд, пока блок открыт. Процент показывается только там, где известен объём работы. Пауза останавливает продолжение этапа; текущий запрос к источнику может завершиться.
Lenci C, De Felice F, Tomaciello M, Caiazzo R, Arcieri S, Fantoni M, Montalto G, Magnante A L, Minniti G
Аннотация
AIMS: Precise patient positioning is critical for successful radiotherapy (RT) in right-sided breast cancer, ensuring adequate tumour coverage while sparing organs at risk (OARs). Conventional tattoo-based setups can cause patient distress. Surface-guided radiotherapy (SGRT) using systems like AlignRT offers a promising, noninvasive alternative. This prospective single-centre study compared the accuracy and reproducibility of SGRT versus conventional tattoo-based positioning for right-sided breast cancer RT.
MATERIALS AND METHODS: Eligible patients underwent a crossover study design, receiving both positioning methods at different points in their treatment. Setup errors were quantified from pretreatment cone-beam computed tomography (CT) registrations. Observations were analysed for each group. Data were analysed using the Shapiro-Wilk test for normality and independent two-sample t-tests to compare positioning errors.
RESULTS: A total of 52 patients were enrolled, and a total of 136 observations were analysed for each group. SGRT positioning resulted in significantly lower mean errors compared to the tattoo-based method across all three directions: longitudinal (P < 0.001), vertical (P < 0.001) and lateral (P = 0.044). Box plot analysis confirmed SGRT had less inter-fraction variability and fewer clinically significant outliers (errors >1 cm), demonstrating superior setup stability.
CONCLUSIONS: SGRT with AlignRT provides superior accuracy and reproducibility for patient positioning in right-sided breast cancer RT. This approach enhances treatment precision, reduces setup variability, and improves patient experience by eliminating the need for permanent tattoos. Future studies are warranted to confirm these findings and assess long-term clinical outcomes.
MATERIALS AND METHODS: Eligible patients underwent a crossover study design, receiving both positioning methods at different points in their treatment. Setup errors were quantified from pretreatment cone-beam computed tomography (CT) registrations. Observations were analysed for each group. Data were analysed using the Shapiro-Wilk test for normality and independent two-sample t-tests to compare positioning errors.
RESULTS: A total of 52 patients were enrolled, and a total of 136 observations were analysed for each group. SGRT positioning resulted in significantly lower mean errors compared to the tattoo-based method across all three directions: longitudinal (P < 0.001), vertical (P < 0.001) and lateral (P = 0.044). Box plot analysis confirmed SGRT had less inter-fraction variability and fewer clinically significant outliers (errors >1 cm), demonstrating superior setup stability.
CONCLUSIONS: SGRT with AlignRT provides superior accuracy and reproducibility for patient positioning in right-sided breast cancer RT. This approach enhances treatment precision, reduces setup variability, and improves patient experience by eliminating the need for permanent tattoos. Future studies are warranted to confirm these findings and assess long-term clinical outcomes.