The Journal of reproductive medicine · 2008
Recombinant factor VIIa to treat late radiation-induced hemorrhagic cystitis: a case report.
Клинический случайСтатьяНазвание и аннотация: Перевод в очереди
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Geisler John P, Linnemeier Georgiann C, Manahan Kelly J
Аннотация
BACKGROUND: Late radiation cystitis is one of the most difficult complications of radiation therapy for pelvic malignancies.
CASE: A 29-year-old woman with a history of cervical cancer presented with radiation-induced hemorrhagic cystitis. The patient received multiple units of packed red blood cells while undergoing several intravesical treatments, including continuous bladder irrigation, 4% formalin, 0.15% AgNO3 and Mg(OH)2 with Al(OH)3. The bleeding finally was stopped by the use of intravenous recombinant factor VIIa.
CONCLUSION: When hemorrhagic cystitis related to late radiation complications is refractory to conventional management, intravenous recombinant factor VIIa may be of benefit.
CASE: A 29-year-old woman with a history of cervical cancer presented with radiation-induced hemorrhagic cystitis. The patient received multiple units of packed red blood cells while undergoing several intravesical treatments, including continuous bladder irrigation, 4% formalin, 0.15% AgNO3 and Mg(OH)2 with Al(OH)3. The bleeding finally was stopped by the use of intravenous recombinant factor VIIa.
CONCLUSION: When hemorrhagic cystitis related to late radiation complications is refractory to conventional management, intravenous recombinant factor VIIa may be of benefit.