Recombinant factor VIIa to treat late radiation-induced hemorrhagic cystitis: a case report.

BACKGROUND

Late radiation cystitis is one of the most difficult complications of radiation therapy for pelvic malignancies.

CASE: A 29-year-old woman with a history of cervical cancer presented with radiation-induced hemorrhagic cystitis. The patient received multiple units of packed red blood cells while undergoing several intravesical treatments, including continuous bladder irrigation, 4% formalin, 0.15% AgNO3 and Mg(OH)2 with Al(OH)3. The bleeding finally was stopped by the use of intravenous recombinant factor VIIa.

CONCLUSION

When hemorrhagic cystitis related to late radiation complications is refractory to conventional management, intravenous recombinant factor VIIa may be of benefit.