Eastern Mediterranean health journal = La revue de sante de la Mediterranee orientale = al-Majallah al-sihhiyah li-sharq al-mutawassit · 2002
Effect of dimethyl diphenyl bicarboxylate on normal and chemically-injured liver.
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el-Sawy S A, el-Shafey A M, el-Bahrawy H A
Аннотация
This study evaluates the effect of DDB on normal and chemically-injured liver. When given to normal rats DDB had no significant effect on liver enzymes, but in chemically-injured rats there was a significant decrease in the elevated levels of liver enzymes. DDB produced a significant increase in reduced glutathione, glutathione peroxidase and glutathione reductase, and a significant decrease in malondialdehyde and glucose-6-phosphate dehydrogenase in both normal and chemically-injured liver. The histopathology examinations showed a slight improvement with DDB administration. DDB has a beneficial effect on liver enzymes and possesses significant antioxidant properties in normal and chemically-injured liver, and may therefore be clinically useful in treating chronic viral hepatitis B in humans.
Предметные рубрики MeSH
Adjuvants, ImmunologicAdministration, OralAnimalsAntioxidantsCarbon TetrachlorideChemical and Drug Induced Liver InjuryCytochrome P-450 Enzyme InhibitorsDioxolesDisease Models, AnimalDrug Evaluation, PreclinicalDrugs, Chinese HerbalGlucosephosphate DehydrogenaseGlutathioneGlutathione PeroxidaseGlutathione ReductaseLiverLiver DiseasesLiver Function TestsMaleMalondialdehydeRatsTime Factors