Mini reviews in medicinal chemistry · 2025
The Application of the Pyrazole Structure in the Structural Modification of Natural Products.
СтатьяОбзорНазвание и аннотация: Перевод в очереди
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Sun Fu-Qun, Wang Ya-Lan, Sun Ke, Yue Fei-Xia, Sun Yun-Xia, Ju Jia-Hong, Jin Zhan-Hui, Shen Qing-Kun, Guo Hong-Yan, Liu Mei-Hui, Quan Zhe-Shan
Аннотация
Most natural products in nature have broad but not exceedingly good biological activities. The pyrazole structure has been introduced into natural products due to its suitability for various synthetic methods and its broad pharmacological activities. This article provides a detailed introduction to the anti-inflammatory, antibacterial, antifungal, antiviral, and anti-Alzheimer disease activities of pyrazole-modified natural product derivatives, particularly their anti-tumor activity. It is worth noting that compared to lead compounds, most natural product derivatives modified with pyrazole exhibit excellent pharmacological activity. Some of these derivatives exhibit outstanding anti- tumor activity, with IC50 values reaching nanomolar levels. This review provides more research directions and choices for future studies on natural products.