Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials · 2002
[Effect of tanshinone IIA on CCl4-induced liver fibrosis in rats].
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Liu Yonggang, Chen Houchang, Jiang Yiping
Аннотация
OBJECTIVE: To study the effect of tanshinone IIA on liver fibrosis in rats induced by CCl4.
METHODS: Model of liver fibrosis in rats were induced by subcutaneous injection of CCl4 and malotilate was as positive control. The histological changes were observed with light microscope. The levels of ALT, AST, NO, HA, LN in serum and Hyp, MDA in liver tissue were determined to reveal the event liver damage.
RESULT: Tanshinone IIA could significantly reduce the elevate levels of ALT, AST, NO, HA, LN in serum and Hyp, MDA in liver tissue. Pathological examination suggested tanshinone IIA has therapecuical effect on experimental liver fibrosis.
CONCLUSION: Tanshinone IIA may have therapeutical effect on CCL4-induced liver fibrosis in rats.
METHODS: Model of liver fibrosis in rats were induced by subcutaneous injection of CCl4 and malotilate was as positive control. The histological changes were observed with light microscope. The levels of ALT, AST, NO, HA, LN in serum and Hyp, MDA in liver tissue were determined to reveal the event liver damage.
RESULT: Tanshinone IIA could significantly reduce the elevate levels of ALT, AST, NO, HA, LN in serum and Hyp, MDA in liver tissue. Pathological examination suggested tanshinone IIA has therapecuical effect on experimental liver fibrosis.
CONCLUSION: Tanshinone IIA may have therapeutical effect on CCL4-induced liver fibrosis in rats.