Tolerance during sedation in a pediatric ICU patient: effects on the BIS monitor.

The authors demonstrate the effects of tolerance as measured using the bispectral index (BIS) monitor. Over a 5-day period, there was a twofold increase in the dose of midazolam and a threefold increase in the dose of fentanyl required to provide the same level of sedation and the same BIS number in a 9 year old boy receiving sedation during mechanical ventilation.