Zhonghua yu fang yi xue za zhi [Chinese journal of preventive medicine] · 2002
[Green tea extracts protected against carbon tetrachloride-induced chronic liver damage and cirrhosis].
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Xiao Jiping, Lu Ruifang, Shen Xinnan, Wu Min
Аннотация
OBJECTIVE: Using the carbon tetrachloride liver cirrhosis rat model, the protective effect of the green tea extractive (GTE) on the liver cirrhosis was studied.
METHODS: Male SD rats were randomly divided into three groups: normal group, GTE group and cirrhosis group. The GTE group and the cirrhosis group were injected subcutanuously 2 times/wk over 9 weeks with 40% CCl(4). In the second and the ninth week, the rats were sacrificed to measure MDA and hydroxyproline concentrations and TGF-beta(1) mRNA expression in liver tissue, as well as to conduct histological examination on various organs.
RESULTS: Compared with the cirrhosis group, the MDA and the hydroxyproline concentrations in the GTE group were significantly reduced (P < 0.05). The liver necrosis and cirrhosis were extenuated in the GTE group by means of histologic examination. The expression of the TGF-beta(1) mRNA was reduced significantly in the GTE group.
CONCLUSION: Dietary supplementation of GTE can protect against CCl(4)-induced liver damage and cirrhosis in rats.
METHODS: Male SD rats were randomly divided into three groups: normal group, GTE group and cirrhosis group. The GTE group and the cirrhosis group were injected subcutanuously 2 times/wk over 9 weeks with 40% CCl(4). In the second and the ninth week, the rats were sacrificed to measure MDA and hydroxyproline concentrations and TGF-beta(1) mRNA expression in liver tissue, as well as to conduct histological examination on various organs.
RESULTS: Compared with the cirrhosis group, the MDA and the hydroxyproline concentrations in the GTE group were significantly reduced (P < 0.05). The liver necrosis and cirrhosis were extenuated in the GTE group by means of histologic examination. The expression of the TGF-beta(1) mRNA was reduced significantly in the GTE group.
CONCLUSION: Dietary supplementation of GTE can protect against CCl(4)-induced liver damage and cirrhosis in rats.