[Hepatoprotective effect of several constituents of Lonicera fulvotomentosa hsu et S. C. cheng, and L. macranthoide Hand.-Mazz. on CC1(4) and D-galactosamine induced liver injuries in mice and rats].

OBJECTIVE

To study the hepatoprotective effect of several constituents of Lonicera fulvotomentosa and L. macranthoide on CC1(4) and D-Galactosamine induced liver injury in mice and rats.

METHOD: Mice and rats were given s.c. several constituents of L. fulvotomentosa and L. macranthoide, sGPT, hepatic triglycerides(TG) and malondialdehyde (MDA) were determined.

RESULTS

All the compounds reduced the rise of sGPT and TG induced by CC1(4) and D-Galactosamine. Hepatic MDA formation caused by CC1(4) was also significantly decreased.

CONCLUSION

Several constituents of L. fulvotomentosa and L. macranthoide are effective in decreasing CC1(4) and D-Galactosamine-induced liver injuries, and this effect appears to be due to the decrease of lipid peroxidation of CC1(4).