Voprosy virusologii · 2004
[Antiviral activity of an interferon inducer amixin in experimental West Nile Fever].
Аннотация на английскомСтатьяНазвание и аннотация: Перевод в очереди
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Loginova S Ia, Koval'chuk A V, Borisevich S V, Syromiatnikova S I, Borisevich G V, Pashchenko Iu I, Khamitov R A, Maksimov V A, Shuster A M
Аннотация
Experimental research was undertaken to investigate the use of amixin in prevention, emergency prevention schemes and treatment of mice infected with West Nile fever (WNF) agent, strain Eg-101; the results are indicative of the drug efficiency both in its peroral and subcutaneous administrations. Amixin was shown to be most effective in the former case when administered, 10 mg/kg, in 96 hours before mice were infected as well as during the entire incubation period: lethality protection--46%. In the latter case, the drug was effective, when 3 administration schemes were in use, 10 mg/kg. The maximum degree of protection efficiency was registered with amixin administration according to the emergency prevention scheme: lethality protection--33%. The drug suppresses effectively the WNF virus reproduction in cerebral tissues.