Psychosomatics · 2008
The effect of pegylated interferon-alpha2b and ribavirin on posttraumatic stress disorder symptoms.
Клиническое исследованиеСтатьяНазвание и аннотация: Перевод в очереди
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Dieperink Eric, Leskela Jennie, Dieperink Michael E, Evans Blake, Thuras Paul, Ho Samuel B
Аннотация
BACKGROUND: Patients with chronic psychiatric diagnoses have a prevalence of chronic hepatitis C (HCV) approximately 11 times higher than the general American population. Posttraumatic stress disorder (PTSD) is particularly common among HCV patients.
OBJECTIVE: The authors describe the effect of treatment with pegylated-interferon-alpha(2b) (IFN) and ribavirin for patients with HCV on their posttraumatic stress disorder (PTSD) symptoms.
METHOD: Sixteen patients with HCV and combat-related PTSD were followed for 24 weeks and assessed with self-report measures of PTSD, hostility, and depression.
RESULTS: Depression and Resentment scores significantly increased in five patients treated with IFN and ribavirin, but no significant differences were found in PTSD scores when compared with 11 control patients.
CONCLUSION: The results suggest that patients with PTSD and HCV can be safely treated with anti-viral therapies when they are given appropriate psychiatric care.
OBJECTIVE: The authors describe the effect of treatment with pegylated-interferon-alpha(2b) (IFN) and ribavirin for patients with HCV on their posttraumatic stress disorder (PTSD) symptoms.
METHOD: Sixteen patients with HCV and combat-related PTSD were followed for 24 weeks and assessed with self-report measures of PTSD, hostility, and depression.
RESULTS: Depression and Resentment scores significantly increased in five patients treated with IFN and ribavirin, but no significant differences were found in PTSD scores when compared with 11 control patients.
CONCLUSION: The results suggest that patients with PTSD and HCV can be safely treated with anti-viral therapies when they are given appropriate psychiatric care.
Предметные рубрики MeSH
Antidepressive AgentsAntiviral AgentsDiagnostic and Statistical Manual of Mental DisordersFollow-Up StudiesHepatitis C, ChronicHostilityHumansInterferon alpha-2Interferon-alphaMaleMiddle AgedPolyethylene GlycolsPopulation SurveillancePrevalenceRecombinant ProteinsRibavirinSeverity of Illness IndexStress Disorders, Post-TraumaticSurveys and QuestionnairesVeterans