[OFF-LABEL DRUG USAGE IN THE TREATMENT OF URINARY TRACT INFECTION OF NEWBORNS].

Infectious pathology in the neonatal period is of the leading causes of neonatal morbidity and mortality. Urinary tract infection occurs in 23% of all infectious diseases. The treatment of infectious diseases mainly employs eradication therapy, mostly with anti-bacterial drugs. In practice, the therapy of infants frequently employs prescribing off-label drugs (cephalosporins 1 and 4 generation, macrolides, carbapenem, sulfonamides), which extends the duration of therapy on the average by 37.1% and increases the incidence of adverse reactions on the average by 11.4%. We believe that neonatologists should use drugs in accordance with prescription labeling. Elucidation of age-related restrictions, dosing, administration ways, and therapy duration must be carried out in the framework of clinical investigations. This is important for increasing the efficacy and safety of practical drug therapy.