Insidious Onset of Serotonin Syndrome in a 6-Year-Old Boy.

Serotonin syndrome, characterized by autonomic, neuromuscular, and mental status changes, is an uncommon but well-established risk of psychotropic medications. The presentation can be highly variable, especially when triggered by agents with effects on additional neurotransmitters.1 The presence of a nonspecific prodrome has been reported but poorly characterized and can lead to misattribution of symptoms.2 We describe a case of serotonin syndrome with insidious onset in a boy treated with multiple medications for behavioral dysregulation.