Antioxidation, anti-hyperglycaemia and renoprotective effects of extracellular polysaccharides from Pleurotus eryngii SI-04.

The present study was designed to investigate the anti-hyperglycaemia, hypolipidemia and renoprotective effects of two extracellular polysaccharides (EPS) from the broth of Pleurotus eryngii SI-04 (EPS1 and EPS2) in mice with streptozotocin (STZ)-induced diabetic nephropathy (DN). The results showed that both EPS1 and EPS2 exhibited potential anti-DN effects, including significantly decreasing GLU levels; suppressing ALB, BUN, CRE and UA levels; reducing serum lipid (TC, TG, VLDL-C and LDL-C) levels; improving renal antioxidant status (GSH-Px, SOD, CAT and MDA); and attenuating pathological nephropathy damage. These results demonstrated that both EPS1 and EPS2 exhibited potential antioxidant, anti-hyperglycaemic, and renoprotective effects against STZ-induced DN, indicating that P. eryngii SI-04 could be used as a functional food and natural drug. In addition, the monosaccharide compositions and bond types of these two polysaccharides were analysed.