Arquivos de neuro-psiquiatria · 2008
Proton MR spectroscopy of the foramen of Monro region in patients with tuberous sclerosis complex.
Сравнительное исследованиеСтатьяНазвание и аннотация: Перевод в очереди
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Carvalho-Neto Arnolfo de, Bruck Isac, Antoniuk Sérgio A, Marchiori Edson, Gasparetto Emerson L
Аннотация
PURPOSE: To evaluate with 1H-magnetic resonance spectroscopy (MRS) the metabolites rations of the foramen of Monro's region in patients with tuberous sclerosis complex (TSC).
METHOD: Twelve patients with TSC and an age and gender-matched control group underwent MR imaging at a 1.5T scanner, and 1H-MRS at the foramen of Monro level with a multivoxel acquisition. Similar volumes of interest were selected in each side of the foramen of Monro and in the basal ganglia (lentiform nuclei). The obtained N-acetylaspartate (NAA), creatine (Cr) and choline (Cho) peak amplitude values and ratios were studied. The statistical analysis was performed and p<0.05 was considered statically significant.
RESULTS: There was no significant difference between the NAA/Cr and Cho/Cr ratios near to the foramen of Monro and basal ganglia of the TSC patients compared with the controls (p>0.05).
CONCLUSION: The NAA/Cr and Cho/Cr ratios near to the foramen of Monro and basal ganglia of TSC patients are similar to the rations obtained in the control group.
METHOD: Twelve patients with TSC and an age and gender-matched control group underwent MR imaging at a 1.5T scanner, and 1H-MRS at the foramen of Monro level with a multivoxel acquisition. Similar volumes of interest were selected in each side of the foramen of Monro and in the basal ganglia (lentiform nuclei). The obtained N-acetylaspartate (NAA), creatine (Cr) and choline (Cho) peak amplitude values and ratios were studied. The statistical analysis was performed and p<0.05 was considered statically significant.
RESULTS: There was no significant difference between the NAA/Cr and Cho/Cr ratios near to the foramen of Monro and basal ganglia of the TSC patients compared with the controls (p>0.05).
CONCLUSION: The NAA/Cr and Cho/Cr ratios near to the foramen of Monro and basal ganglia of TSC patients are similar to the rations obtained in the control group.
Предметные рубрики MeSH
Amino AcidsAspartic AcidAstrocytomaBasal GangliaBiomarkers, TumorBrain ChemistryCase-Control StudiesCerebral Ventricle NeoplasmsCerebral VentriclesChildCholineCreatineEarly Detection of CancerFemaleFollow-Up StudiesHumansMagnetic Resonance SpectroscopyMaleProspective StudiesProtonsTuberous Sclerosis