Fertility and sterility · 2008
The effects of oral contraceptives including low-dose estrogen and drospirenone on the concentration of leptin and ghrelin in polycystic ovary syndrome.
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Sağsöz Nevin, Orbak Zerrin, Noyan Volkan, Yücel Aykan, Uçar Banu, Yildiz Leyla
Аннотация
OBJECTIVE: To evaluate short-term leptin and ghrelin concentrations in women with polycystic ovary syndrome (PCOS) who use low-dose oral contraceptives containing drospirenone.
DESIGN: Prospective study.
SETTING: Department of obstetrics and gynaecology in a university hospital.
PATIENT(S): Twenty women with PCOS were enrolled in the study.
INTERVENTION(S): A low-dose oral contraceptive containing ethinyl estradiol and drospirenone was given for three cycles.
MAIN OUTCOME MEASURE(S): Serum androstenedione, free T, T, dehydroepiandrosterone sulphate, sex hormone-binding globulin, FSH, LH, E(2), lipid profiles, leptin, and ghrelin levels were measured in each subject. Insulin resistance was estimated by the homeostasis model assessment-insulin resistance (HOMA-IR).
RESULT(S): While leptin concentrations did not change with therapy, ghrelin levels increased statistically. Baseline leptin concentrations were correlated positively with body mass index, waist-to-hip ratio, insulin, and HOMA-IR and negatively with ghrelin. After controlling for body mass index and waist-to-hip ratio in a partial correlation analysis, leptin levels were not correlated with these parameters. Ghrelin was inversely correlated with body mass index, waist-to-hip ratio, insulin, HOMA-IR, and free T.
CONCLUSION(S): In patients with PCOS, an oral contraceptive containing ethinyl estradiol and drospirenone increases ghrelin levels but not leptin levels in a 3-month period. Ghrelin might be related to the metabolic and androgenic changes in patients with PCOS.
DESIGN: Prospective study.
SETTING: Department of obstetrics and gynaecology in a university hospital.
PATIENT(S): Twenty women with PCOS were enrolled in the study.
INTERVENTION(S): A low-dose oral contraceptive containing ethinyl estradiol and drospirenone was given for three cycles.
MAIN OUTCOME MEASURE(S): Serum androstenedione, free T, T, dehydroepiandrosterone sulphate, sex hormone-binding globulin, FSH, LH, E(2), lipid profiles, leptin, and ghrelin levels were measured in each subject. Insulin resistance was estimated by the homeostasis model assessment-insulin resistance (HOMA-IR).
RESULT(S): While leptin concentrations did not change with therapy, ghrelin levels increased statistically. Baseline leptin concentrations were correlated positively with body mass index, waist-to-hip ratio, insulin, and HOMA-IR and negatively with ghrelin. After controlling for body mass index and waist-to-hip ratio in a partial correlation analysis, leptin levels were not correlated with these parameters. Ghrelin was inversely correlated with body mass index, waist-to-hip ratio, insulin, HOMA-IR, and free T.
CONCLUSION(S): In patients with PCOS, an oral contraceptive containing ethinyl estradiol and drospirenone increases ghrelin levels but not leptin levels in a 3-month period. Ghrelin might be related to the metabolic and androgenic changes in patients with PCOS.