The Journal of clinical endocrinology and metabolism · 2017
Risk of Thyroid Nodules in Residents of Belarus Exposed to Chernobyl Fallout as Children and Adolescents.
СтатьяМногоцентровое исследованиеResearch Support, N.I.H., IntramuralНазвание и аннотация: Перевод в очереди
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Cahoon Elizabeth K, Nadyrov Eldar A, Polyanskaya Olga N, Yauseyenka Vasilina V, Veyalkin Ilya V, Yeudachkova Tamara I, Maskvicheva Tamara I, Minenko Victor F, Liu Wayne, Drozdovitch Vladimir, Mabuchi Kiyohiko, Little Mark P, Zablotska Lydia B, McConnell Robert J, Hatch Maureen, Peters Kamau O, Rozhko Alexander V, Brenner Alina V
Аннотация
CONTEXT: Although radiation exposure is an important predictor of thyroid cancer on diagnosis of a thyroid nodule, the relationship between childhood radiation exposure and thyroid nodules has not been comprehensively evaluated.
OBJECTIVE: To examine the association between internal I-131 thyroid dose and thyroid nodules in young adults exposed during childhood.
DESIGN, SETTING, AND PARTICIPANTS: In this cross-sectional study, we screened residents of Belarus aged ≤18 years at the time of the Chernobyl nuclear accident for thyroid disease (median age, 21 years) with thyroid palpation, ultrasonography, blood/urine analysis, and medical follow-up when appropriate. Eligible participants (N = 11,421) had intact thyroid glands and doses based on direct individual thyroid activity measurements.
MAIN OUTCOME MEASURES: Excess odds ratios per Gray (EOR/Gy, scaled at age 5 years at exposure) for any thyroid nodule and for nodules grouped by cytology/histology, diameter size, and singularity.
RESULTS: Risk of any thyroid nodule increased significantly with I-131 dose and, for a given dose, with younger age at exposure. The EOR/Gy (95% confidence intervals) for neoplastic nodules (3.82; 0.87 to 15.52) was significantly higher than for nonneoplastic nodules (0.32; <0.03 to 0.70) and did not vary by size; whereas the EOR/Gy for nonneoplastic nodules did vary by size (P = 0.02) and was 1.55 (0.36 to 5.46) for nodules ≥10 mm and 0.02 (<-0.02 to 0.70) for nodules <10 mm. EORs/Gy for single and multiple nodules were comparable.
CONCLUSIONS: Childhood exposure to internal I-131 is associated with increased risk of neoplastic thyroid nodules of any size and nonneoplastic nodules ≥10 mm.
OBJECTIVE: To examine the association between internal I-131 thyroid dose and thyroid nodules in young adults exposed during childhood.
DESIGN, SETTING, AND PARTICIPANTS: In this cross-sectional study, we screened residents of Belarus aged ≤18 years at the time of the Chernobyl nuclear accident for thyroid disease (median age, 21 years) with thyroid palpation, ultrasonography, blood/urine analysis, and medical follow-up when appropriate. Eligible participants (N = 11,421) had intact thyroid glands and doses based on direct individual thyroid activity measurements.
MAIN OUTCOME MEASURES: Excess odds ratios per Gray (EOR/Gy, scaled at age 5 years at exposure) for any thyroid nodule and for nodules grouped by cytology/histology, diameter size, and singularity.
RESULTS: Risk of any thyroid nodule increased significantly with I-131 dose and, for a given dose, with younger age at exposure. The EOR/Gy (95% confidence intervals) for neoplastic nodules (3.82; 0.87 to 15.52) was significantly higher than for nonneoplastic nodules (0.32; <0.03 to 0.70) and did not vary by size; whereas the EOR/Gy for nonneoplastic nodules did vary by size (P = 0.02) and was 1.55 (0.36 to 5.46) for nodules ≥10 mm and 0.02 (<-0.02 to 0.70) for nodules <10 mm. EORs/Gy for single and multiple nodules were comparable.
CONCLUSIONS: Childhood exposure to internal I-131 is associated with increased risk of neoplastic thyroid nodules of any size and nonneoplastic nodules ≥10 mm.