Journal of opioid management · 2011
Potency ratio of hydromorphone and diacetylmorphine in substitution treatment for long-term opioid dependency.
Клиническое исследование III фазыСравнительное исследованиеСтатьяМногоцентровое исследованиеРандомизированное исследованиеПоддержка исследования: вне правительства СШАНазвание и аннотация: Перевод в очереди
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Oviedo-Joekes Eugenia, Marsh David C, Guh Daphne, Brissette Suzanne, Schechter Martin T
Аннотация
BACKGROUND: Data on conversion ratios for switching opioids in substitution treatment are limited.
METHODS: Data were obtained from a randomized controlled trial among long-term opioid-dependent patients conducted in Vancouver and Montreal, Canada. Patients received diacetylmorphine (n = 115) or hydromorphone (n = 25) on a double-blind basis, on a 1:3 potency ratio with individually adjusted dosage, both injectable.
RESULTS: Average daily dosages of hydromorphone and diacetylmorphine prescribed were 212.6 mg and 454.0 mg, respectively; potency ratio was 1:2.0-2.2 at different dose ranges.
CONCLUSIONS: Studies using hydromorphone as a diacetylmorphine equivalent should consider the ratio found in this study to achieve equipotency and maintain the blinding.
METHODS: Data were obtained from a randomized controlled trial among long-term opioid-dependent patients conducted in Vancouver and Montreal, Canada. Patients received diacetylmorphine (n = 115) or hydromorphone (n = 25) on a double-blind basis, on a 1:3 potency ratio with individually adjusted dosage, both injectable.
RESULTS: Average daily dosages of hydromorphone and diacetylmorphine prescribed were 212.6 mg and 454.0 mg, respectively; potency ratio was 1:2.0-2.2 at different dose ranges.
CONCLUSIONS: Studies using hydromorphone as a diacetylmorphine equivalent should consider the ratio found in this study to achieve equipotency and maintain the blinding.