DOI 10.3969/j.issn.1672-7347.2011.08.006

Медицинская библиотека · Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences · 2011

Brain function of heroin addicts after withdrawal.

Wang Xuyi, Zhou Xuhui, Liao Yanhui, Tang Jinsong, Liu Tieqiao, Hao Wei

СтатьяПоддержка исследования: вне правительства СШАПеревод в очереди

Аннотация

OBJECTIVE

To explore what brain regions are modulated by heroin addiction and withdrawal.

METHODS

We used functional magnetic resonance imaging to investigate the brain function in 15 heroin-dependent patients 3 days (acute) and 1 month (protracted) after heroin abstinence. Sixteen normal controls were included.

RESULTS

The blood oxygen level-dependent signal in the orbitofrontal cortex of the brain of heroin-dependent patients was significantly elevated 3 days after the withdrawal. Hyperfunction of the orbitofrontal cortex declined 1 month after the withdrawal.

CONCLUSION

Heroin-dependent subjects at both 3 days and 1 month abstinence have persistent abnormalities in the brain function. Although some tangible beneficial effects are noted following 1 month of detoxification, possible permanent damage to the brain caused by heroin use is suggested.

Для цитирования: Wang Xuyi, Zhou Xuhui, Liao Yanhui, Tang Jinsong, Liu Tieqiao, Hao Wei. Brain function of heroin addicts after withdrawal.. Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences. 2011. DOI: 10.3969/j.issn.1672-7347.2011.08.006.

Предметные рубрики MeSH

Adult Brain Case-Control Studies Heroin Dependence Humans Magnetic Resonance Imaging Male Substance Withdrawal Syndrome

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