Linkage to chromosome 1p36 for attention-deficit/hyperactivity disorder traits in school and home settings.
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Zhou Kaixin, Asherson Philip, Sham Pak, Franke Barbara, Anney Richard J L, Buitelaar Jan, Ebstein Richard, Gill Michael, Brookes Keeley, Buschgens Cathelijne, Campbell Desmond, Chen Wai, Christiansen Hanna, Fliers Ellen, Gabriëls Isabel, Johansson Lena, Marco Rafaela, Mulas Fernando, Müller Ueli, Mulligan Aisling, Neale Benjamin M, Rijsdijk Fruhling, Rommelse Nanda, Uebel Henrik, Psychogiou Lamprini, Xu Xiaohui, Banaschewski Tobias, Sonuga-Barke Edmund, Eisenberg Jacques, Manor Iris, Miranda Ana, Oades Robert D, Roeyers Herbert, Rothenberger Aribert, Sergeant Joseph, Steinhausen Hans-Christoph, Taylor Eric, Thompson Margaret, Faraone Stephen V
Аннотация
METHODS: A set of 1094 single selected Caucasian ADHD nuclear families was genotyped on a highly accurate and informative single nucleotide polymorphism (SNP) panel. Two quantitative traits measuring the children's symptoms in home and school settings were collected and standardized according to a population sample of 8000 children to reflect the developmental nature and gender prevalence difference of ADHD. Univariate linkage test was performed on both traits and their mean score.
RESULTS: A significant common linkage locus was found at chromosome 1p36 with a locus-specific heritability of 5.1% and a genomewide empirical p < .04. Setting-specific suggestive linkage signals were also found: logarithm of odds (LOD) = 2.2 at 9p23 for home trait and LOD = 2.6 at 11q21 for school trait.
CONCLUSIONS: These results indicate that given large samples with proper phenotypic measures, searching for ADHD genes with a QTL strategy is an important alternative to using the clinical diagnosis. The fact that our linkage region 1p36 overlaps with the dyslexia QTL DYX8 further suggests it is potentially a pleiotropic locus for ADHD and dyslexia.