Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology · 2021
Resting state brain network functional connectivity is not associated with inflammatory markers and blood cell counts in older adults.
Клиническое исследованиеСтатьяПоддержка исследования: вне правительства СШАНазвание и аннотация: Перевод в очереди
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Lichtner Gregor, Zacharias Norman, Spies Claudia D, Feinkohl Insa, Winterer Georg, Pischon Tobias, von Dincklage Falk, BioCog Consortium
Аннотация
OBJECTIVE: Systemic inflammation and monocyte counts have previously been associated with changes in resting state functional connectivity (rsFC) in cross-sectional neuroimaging studies. We therefore investigated this association in a longitudinal study of older patients.
METHODS: We performed a secondary analysis of longitudinal data from older patients who underwent functional magnet resonance imaging (fMRI) scans before and 3 months after elective surgery. Additionally, serum levels of C-reactive protein and Interleukin-6 as markers of inflammation and leukocyte, lymphocyte and monocyte counts were determined. Correlations between these markers and pre- or postoperative rsFC between regions previously associated with inflammatory markers were investigated using general linear regression models.
RESULTS: We found no significant correlations between inflammatory markers or blood cell counts and mean connectivity within four resting state networks (RSNs), neither preoperatively nor postoperatively. Significant inter-region rsFC was found within these RSNs between a few regions either pre- or postoperatively, but no inter-region connections were consistently observed in both pre- and postoperative fMRI scans.
CONCLUSIONS: Inflammatory markers and monocyte counts were not associated with rsFC in our study, contrasting previous results.
SIGNIFICANCE: Multiple measurements in the same individuals, as performed here, provide a way to reduce the high risk of false positive results in fMRI studies.
TRIAL REGISTRATION: Clinicaltrials.gov (registration number NCT02265263).
METHODS: We performed a secondary analysis of longitudinal data from older patients who underwent functional magnet resonance imaging (fMRI) scans before and 3 months after elective surgery. Additionally, serum levels of C-reactive protein and Interleukin-6 as markers of inflammation and leukocyte, lymphocyte and monocyte counts were determined. Correlations between these markers and pre- or postoperative rsFC between regions previously associated with inflammatory markers were investigated using general linear regression models.
RESULTS: We found no significant correlations between inflammatory markers or blood cell counts and mean connectivity within four resting state networks (RSNs), neither preoperatively nor postoperatively. Significant inter-region rsFC was found within these RSNs between a few regions either pre- or postoperatively, but no inter-region connections were consistently observed in both pre- and postoperative fMRI scans.
CONCLUSIONS: Inflammatory markers and monocyte counts were not associated with rsFC in our study, contrasting previous results.
SIGNIFICANCE: Multiple measurements in the same individuals, as performed here, provide a way to reduce the high risk of false positive results in fMRI studies.
TRIAL REGISTRATION: Clinicaltrials.gov (registration number NCT02265263).