Archives of neurology · 2008
Increased frequency of learning disability in patients with primary progressive aphasia and their first-degree relatives.
Сравнительное исследованиеСтатьяПоддержка NIH: внешняя программаНазвание и аннотация: Перевод в очереди
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Rogalski Emily, Johnson Nancy, Weintraub Sandra, Mesulam Marsel
Аннотация
BACKGROUND: Although risk factors for Alzheimer disease have been well studied, much less is known about risk factors for primary progressive aphasia (PPA).
OBJECTIVE: To demonstrate that learning disabilities (LDs) are more common in patients with PPA and their first-degree family members.
DESIGN, SETTING, AND PATIENTS: Self-report endorsement of an individual and family history of an LD in a sample of 699 subjects from the Northwestern Alzheimer's Disease Center registry. We compared 3 dementia groups (PPA, typical amnestic Alzheimer disease, and the behavioral variant of frontotemporal dementia) and 1 elderly control group. A retrospective medical record review in the PPA probands was used to obtain additional information.
MAIN OUTCOME MEASURE: Prevalence of LDs among probands and their first-degree relatives.
RESULTS: The patients with PPA and their first-degree family members had a significantly higher frequency of LD compared with the other dementia groups and the controls. Some of the families of patients with PPA displayed unusual concentrations of LD, especially dyslexia.
CONCLUSION: These results suggest that LD may constitute a risk factor for PPA, providing additional clues concerning the determinants for the selective vulnerability of the language network in this syndrome.
OBJECTIVE: To demonstrate that learning disabilities (LDs) are more common in patients with PPA and their first-degree family members.
DESIGN, SETTING, AND PATIENTS: Self-report endorsement of an individual and family history of an LD in a sample of 699 subjects from the Northwestern Alzheimer's Disease Center registry. We compared 3 dementia groups (PPA, typical amnestic Alzheimer disease, and the behavioral variant of frontotemporal dementia) and 1 elderly control group. A retrospective medical record review in the PPA probands was used to obtain additional information.
MAIN OUTCOME MEASURE: Prevalence of LDs among probands and their first-degree relatives.
RESULTS: The patients with PPA and their first-degree family members had a significantly higher frequency of LD compared with the other dementia groups and the controls. Some of the families of patients with PPA displayed unusual concentrations of LD, especially dyslexia.
CONCLUSION: These results suggest that LD may constitute a risk factor for PPA, providing additional clues concerning the determinants for the selective vulnerability of the language network in this syndrome.