Anthropometric factors and risk of endometrial cancer: the European prospective investigation into cancer and nutrition.
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Friedenreich Christine, Cust Anne, Lahmann Petra H, Steindorf Karen, Boutron-Ruault Marie-Christine, Clavel-Chapelon Françoise, Mesrine Sylvie, Linseisen Jakob, Rohrmann Sabine, Boeing Heiner, Pischon Tobias, Tjønneland Anne, Halkjaer Jytte, Overvad Kim, Mendez Michelle, Redondo M L, Garcia Carmen Martinez, Larrañaga Nerea, Tormo María-José, Gurrea Aurelio Barricarte, Bingham Sheila, Khaw Kay-Tee, Allen Naomi, Key Tim, Trichopoulou Antonia, Vasilopoulou Effie, Trichopoulos Dimitrios, Pala Valeria, Palli Domenico, Tumino Rosario, Mattiello Amalia, Vineis Paolo, Bueno-de-Mesquita H Bas, Peeters Petra H M, Berglund Göran, Manjer Jonas, Lundin Eva, Lukanova Annekatrin, Slimani Nadia, Jenab Mazda, Kaaks Rudolf, Riboli Elio
Аннотация
METHODS: Among 223,008 women in the European Prospective Investigation into Cancer and Nutrition (EPIC) study, there were 567 incident endometrial cancer cases during 6.4 years of follow-up. The analysis was performed with Cox proportional hazards modeling.
RESULTS: Weight, body mass index (BMI), waist and hip circumferences and waist-hip ratio (WHR) were strongly associated with increased risk of endometrial cancer. The relative risk (RR) for obese (BMI 30- < 40 kg/m(2)) compared to normal weight (BMI < 25) women was 1.78, 95% CI = 1.41-2.26, and for morbidly obese women (BMI > or = 40) was 3.02, 95% CI = 1.66-5.52. The RR for women with a waist circumference of > or =88 cm vs. <80 cm was 1.76, 95% CI = 1.42-2.19. Adult weight gain of > or =20 kg compared with stable weight (+/-3 kg) increased risk independent of body weight at age 20 (RR = 1.75, 95% CI = 1.11-2.77). These associations were generally stronger for postmenopausal than premenopausal women, and oral contraceptives never-users than ever-users, and much stronger among never-users of hormone replacement therapy compared to ever-users.
CONCLUSION: Obesity, abdominal adiposity, and adult weight gain were strongly associated with endometrial cancer risk. These associations were particularly evident among never-users of hormone replacement therapy.