In vivo continuous monitoring of K+ in animals using ISFET probes.

Potassium ion sensitive field effect transistor probes have been developed and tested in various clinical applications involving continuous monitoring of serum and interstitial fluid potassium levels. Initial results are presented that demonstrate the importance of continuous monitoring of serum and/or IF K+. Probe construction, calibration, and in vivo placement techniques are described. Use of continuous monitoring that ChemFET probes provide offers the potential for much improved management of patients recovering from many types of clinical disease states that may involve electrolyte abnormalities. Further studies are in progress that will provide additional insight into electrolyte dynamics among the various fluid compartments of the body in response to various physiological stresses.