The ability of athymic nude mice to survive intracerebral infection of lymphocytic choriomeningitis (LCM) virus.

Adult athymic nude mice were protected against the lethality of intracerebral infection with LCM virus. Although the multiplication of LCM virus in the brain was almost equal between nu/nu and nu/+ mice, the delayed hypersensitivity reaction was not evoked in nu/nu mice as evidenced by foot pad reaction.