Arquivos de neuro-psiquiatria · 2004
[Vigabatrin in the treatment of epilepsy in patients with West syndrome and tuberous sclerosis].
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Rotta Newra Tellechea, da Silva Alexandre Rodrigues, Ohlweiler Lygia, Riesgo Rudimar
Аннотация
PURPOSE: To report the efficacy of vigabatrin in seizures control, as well as the electroencephalographic abnormalities in children with tuberous sclerosis and West syndrome.
METHOD: Retrospective study, with clinical, neuroimaging, and electroencephalographic data.
RESULTS: Seven patients were followed, and the median time of follow-up was 10 years. Four of them were females and all were white. The mean age of seizures onset was 3.4 months. All patients used antiepileptic drugs associations, at least 2 drugs each therapeutic scheme, each one of the patients have used at least two different schemes. Vigabatrin as monotherapy or adjuvant was started in a mean age of seven years or 4 years after the onset of symptoms. Five from seven patients on vigabatrin became seizure free.
CONCLUSION: Vigabatrin was efficient in seizures control, leading to a better prognosis.
METHOD: Retrospective study, with clinical, neuroimaging, and electroencephalographic data.
RESULTS: Seven patients were followed, and the median time of follow-up was 10 years. Four of them were females and all were white. The mean age of seizures onset was 3.4 months. All patients used antiepileptic drugs associations, at least 2 drugs each therapeutic scheme, each one of the patients have used at least two different schemes. Vigabatrin as monotherapy or adjuvant was started in a mean age of seven years or 4 years after the onset of symptoms. Five from seven patients on vigabatrin became seizure free.
CONCLUSION: Vigabatrin was efficient in seizures control, leading to a better prognosis.