Primary care respiratory journal : journal of the General Practice Airways Group · 2011
Disease severity and symptoms among patients receiving monotherapy for COPD.
СтатьяПоддержка исследования: вне правительства СШАНазвание и аннотация: Перевод в очереди
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Dransfield Mark T, Bailey William, Crater Glenn, Emmett Amanda, O'Dell Dianne M, Yawn Barbara
Аннотация
AIM: To examine the burden of respiratory symptoms, quality of life and co-morbid illness in COPD patients receiving maintenance treatment in a real world setting.
METHODS: In a single visit, patients with a physician's diagnosis of COPD who were receiving monotherapy with a long-acting bronchodilator (LABD) performed spirometry, completed symptom questionnaires, and reported their treatments, history of exacerbations and co-morbidities.
RESULTS: We enrolled 1084 patients of whom 1072 had acceptable spirometry. 689 (64%) had airflow obstruction (FEV1/FVC≤0.70) while 383 (36%) failed to meet spirometric criteria for COPD despite receiving maintenance therapy and having comparable symptoms and comorbid illness. Among those with confirmed COPD, dyspnoea was worse in those with more severe airflow limitation though exacerbation frequency was comparable across COPD stages.
CONCLUSIONS: COPD is commonly diagnosed and treated in patients without airflow obstruction. Many COPD patients receiving LABD monotherapy continue to suffer significant symptoms, exacerbations and poor quality of life.
METHODS: In a single visit, patients with a physician's diagnosis of COPD who were receiving monotherapy with a long-acting bronchodilator (LABD) performed spirometry, completed symptom questionnaires, and reported their treatments, history of exacerbations and co-morbidities.
RESULTS: We enrolled 1084 patients of whom 1072 had acceptable spirometry. 689 (64%) had airflow obstruction (FEV1/FVC≤0.70) while 383 (36%) failed to meet spirometric criteria for COPD despite receiving maintenance therapy and having comparable symptoms and comorbid illness. Among those with confirmed COPD, dyspnoea was worse in those with more severe airflow limitation though exacerbation frequency was comparable across COPD stages.
CONCLUSIONS: COPD is commonly diagnosed and treated in patients without airflow obstruction. Many COPD patients receiving LABD monotherapy continue to suffer significant symptoms, exacerbations and poor quality of life.
Предметные рубрики MeSH
Administration, InhalationAdultAge FactorsAgedAlbuterolBronchodilator AgentsComorbidityConfidence IntervalsCross-Sectional StudiesDisease ProgressionDose-Response Relationship, DrugDyspneaFemaleHumansMaleMiddle AgedPrognosisPulmonary Disease, Chronic ObstructiveQuality of LifeRespiratory Function TestsRisk AssessmentSeverity of Illness IndexSex FactorsSpirometryTreatment OutcomeVital Capacity