Terapevticheskii arkhiv · 2004
[Administration of essential phospholipids in persons exposed to chemical industrial pollutants].
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Shpagina L A, Bobrov S V
Аннотация
AIM: To examine efficacy of the drug essliver-forte in patients with chronic intoxication by a complex of such toxicants as soluble and unsoluble compounds of uranium, lead and mercury.
MATERIAL AND METHODS: The examination of bilirubin, synthesis of proteins and enzyme production by the liver, activity of free radical lipid oxidation and antioxidant defence was conducted in 42 persons (mean age 66.4 +/- 4.2 years) occupationally exposed to chemicals (compounds of uranium, lead and mercury) for 12.6 +/- 1.8 years. The patients were divided into two equal groups: patients of group 1 received standard therapy with enterosorbents, cerebral angioprotectors and alpha-tocopherol; patients of group 2 instead of alpha-tocopherol were given essliver-forte (2 capsules twice a day).
RESULTS: Patients of group 2 had significantly less frequent complaints for fatigue, anxiety, dyspnea, sleep disorders; improvement was observed in peripheral blood counts, in concentrations of alpha 2- and gamma-globulins, sulfhydril and catalase activity of erythrocytes; transaminase activity and intensity of saponin hemolysis went down.
CONCLUSION: Essliver-forte is effective in persons occupationally exposed to chemicals.
MATERIAL AND METHODS: The examination of bilirubin, synthesis of proteins and enzyme production by the liver, activity of free radical lipid oxidation and antioxidant defence was conducted in 42 persons (mean age 66.4 +/- 4.2 years) occupationally exposed to chemicals (compounds of uranium, lead and mercury) for 12.6 +/- 1.8 years. The patients were divided into two equal groups: patients of group 1 received standard therapy with enterosorbents, cerebral angioprotectors and alpha-tocopherol; patients of group 2 instead of alpha-tocopherol were given essliver-forte (2 capsules twice a day).
RESULTS: Patients of group 2 had significantly less frequent complaints for fatigue, anxiety, dyspnea, sleep disorders; improvement was observed in peripheral blood counts, in concentrations of alpha 2- and gamma-globulins, sulfhydril and catalase activity of erythrocytes; transaminase activity and intensity of saponin hemolysis went down.
CONCLUSION: Essliver-forte is effective in persons occupationally exposed to chemicals.