[Local treatment of Von Willebrand's disease--use of GRF adhesive].

Among the systemic hemorrhagic we find Von Willebrand's, the most prevalent coagulation related illness. It may be defined as a qualitative platelet abnormality which in most cases is transmitted as a dominant mendelian trait. Clinically there is prolonged bleeding time, epistaxis, gingival hemorrhage and increased bleeding after surgery or dental extractions. The purpose of this project was to test the effectivity of a local element such as GRF glue as the only treatment for these patients. With the purpose to avoid the use of a substitute therapy, mainly taking into consideration all the problems derived from the AIDS virus. It was concluded that GRF glue was an excellent local treatment for Von Willebrand's carries with factor VIII over 10%. Systemic therapy must be instituted in patients under the 10% circulating factor VIII.