Aspirin and Reye's syndrome. How strong an association?

The alleged association between aspirin and Reye's syndrome has elicited a great deal of public and professional concern and has had a significant impact on pediatric medicine. Indeed, many health agencies are currently warning against giving aspirin to children with viral infections. In this article, Dr Orlowski reviews the data upon which precautions against aspirin use have been based and attempts to answer the question of whether such precautions are premature or warranted.