Emerging infectious diseases · 2011
Use of antiviral drugs to reduce household transmission of pandemic (H1N1) 2009, United Kingdom.
СтатьяНазвание и аннотация: Перевод в очереди
Обработка статьи · этапы, ошибки и управление
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Ошибки и ограничения
История · было → стало
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Pebody Richard G, Harris Ross, Kafatos George, Chamberland Mary, Campbell Colin, Nguyen-Van-Tam Jonathan S, McLean Estelle, Andrews Nick, White Peter J, Wynne-Evans Edward, Green Jon, Ellis Joanna, Wreghitt Tim, Bracebridge Sam, Ihekweazu Chikwe, Oliver Isabel, Smith Gillian, Hawkins Colin, Salmon Roland, Smyth Bryan, McMenamin Jim, Zambon Maria, Phin Nick, Watson John M
Аннотация
The United Kingdom implemented a containment strategy for pandemic (H1N1) 2009 through administering antiviral agents (AVs) to patients and their close contacts. This observational household cohort study describes the effect of AVs on household transmission. We followed 285 confirmed primary cases in 259 households with 761 contacts. At 2 weeks, the confirmed secondary attack rate (SAR) was 8.1% (62/761) and significantly higher in persons <16 years of age than in those >50 years of age (18.9% vs. 1.2%, p<0.001). Early (<48 hours) treatment of primary case-patients reduced SAR (4.5% vs. 10.6%, p = 0.003). The SAR in child contacts was 33.3% (10/30) when the primary contact was a woman and 2.9% (1/34) when the primary contact was a man (p = 0.010). Of 53 confirmed secondary case-patients, 45 had not received AV prophylaxis. The effectiveness of AV prophylaxis in preventing infection was 92%.