Archives of neurology · 2004
Left hemicranial hypoplasia in 2 patients with primary progressive aphasia.
Клиническое исследованиеСтатьяПоддержка службы здравоохранения СШАНазвание и аннотация: Перевод в очереди
Обработка статьи · этапы, ошибки и управление
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Alberca Román, Montes Enrique, Russell Eric, Gil-Néciga Eulogio, Mesulam Marsel
Аннотация
BACKGROUND: Primary progressive aphasia (PPA) leads to a gradual and relatively isolated dissolution of language function. The factors that determine the selectivity of the disease process remain unknown. We had speculated that PPA may occasionally arise as a tardive manifestation of genetic or acquired vulnerabilities involving the language network of the brain.
OBJECTIVE: To explore predisposing factors for PPA.
RESULTS: In 2 patients, PPA developed with a background of mild left hemicranial hypoplasia.
CONCLUSION: In keeping with other observations of PPA in patients with dyslexia and childhood injury to the left temporal lobe, these 2 patients support the contention that some cases of PPA may arise in settings where the language network has become a locus of least resistance.
OBJECTIVE: To explore predisposing factors for PPA.
RESULTS: In 2 patients, PPA developed with a background of mild left hemicranial hypoplasia.
CONCLUSION: In keeping with other observations of PPA in patients with dyslexia and childhood injury to the left temporal lobe, these 2 patients support the contention that some cases of PPA may arise in settings where the language network has become a locus of least resistance.