Singapore medical journal · 1998
Complicated varicella zoster infection in 8 paediatric patients and review of literature.
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Phuah H K, Chong C Y, Lim K W, Cheng H K
Аннотация
BACKGROUND: This is a study of complicated varicella zoster infection in paediatric patients.
AIM: To find out the number of patients with such complications, the types of complications and their outcome.
METHOD: This involved a retrospective review of the case records of 8 patients who presented to our unit over a 12-month period (Jan-Dec 96). All patients were previously well without any underlying immunodeficiency. Varicella zoster (VZ) infection was confirmed by VZ immunofluorescence from vesicular fluid.
RESULTS: CMS complications accounted for 6 of the 8 cases. Of these, 3 presented with encephalitis, 2 with cerebella ataxia and 1 with aseptic meningitis and cerebella ataxia. Of the non-CNS cases, 1 presented with glomerulonephritis with superimposed staphylococcus infection of skin ulcers; the other had disseminated VZ infection with haemorrhagic vesicles, hepatitis, ileus with mesenteric adenitis and disseminated intravascular coagulation.
OUTCOME: The patient with disseminated VZ infection and multiple organ involvement died 5 days after a stormy course. One patient with encephalitis who had status epilepticus for 2 hours had behavioural problems and poor memory. The remaining 6 patients had no sequelae.
CONCLUSION: VZ infection usually a minor illness, can result in serious life-threatening complications in previously healthy patients.
AIM: To find out the number of patients with such complications, the types of complications and their outcome.
METHOD: This involved a retrospective review of the case records of 8 patients who presented to our unit over a 12-month period (Jan-Dec 96). All patients were previously well without any underlying immunodeficiency. Varicella zoster (VZ) infection was confirmed by VZ immunofluorescence from vesicular fluid.
RESULTS: CMS complications accounted for 6 of the 8 cases. Of these, 3 presented with encephalitis, 2 with cerebella ataxia and 1 with aseptic meningitis and cerebella ataxia. Of the non-CNS cases, 1 presented with glomerulonephritis with superimposed staphylococcus infection of skin ulcers; the other had disseminated VZ infection with haemorrhagic vesicles, hepatitis, ileus with mesenteric adenitis and disseminated intravascular coagulation.
OUTCOME: The patient with disseminated VZ infection and multiple organ involvement died 5 days after a stormy course. One patient with encephalitis who had status epilepticus for 2 hours had behavioural problems and poor memory. The remaining 6 patients had no sequelae.
CONCLUSION: VZ infection usually a minor illness, can result in serious life-threatening complications in previously healthy patients.
Предметные рубрики MeSH
Cerebellar AtaxiaChickenpoxChildChild Behavior DisordersChild, PreschoolDisseminated Intravascular CoagulationEncephalitis, ViralFatal OutcomeFemaleFluorescent Antibody TechniqueGlomerulonephritisHepatitis, Viral, HumanHerpesvirus 3, HumanHumansInfantIntestinal ObstructionLymphadenitisMaleMemory DisordersMeningitis, AsepticRetrospective StudiesSkin UlcerStaphylococcal InfectionsStatus Epilepticus