European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences · 2009
Evaluation of the efficacy and safety of a statin/caffeine combination against H5N1, H3N2 and H1N1 virus infection in BALB/c mice.
Сравнительное исследованиеСтатьяНазвание и аннотация: Перевод в очереди
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Liu Zeyu, Guo Zhongmin, Wang Guoling, Zhang Dingmei, He Hongxuan, Li Guowei, Liu Yuge, Higgins Denise, Walsh Aoiffe, Shanahan-Prendergast Leo, Lu Jiahai
Аннотация
The development of novel antiviral drugs is necessary for the prevention and treatment of a potential avian influenza pandemic. The aim of this study was to evaluate the efficacy and safety of a novel statin/caffeine combination against H5N1, H3N2 and H1N1 virus infection in a murine model. In H5N1-, H3N2- and H1N1-infected BALB/c mice, 50mug statin/200mug caffeine effectively ameliorated lung damage and inhibited viral replication and was at least as effective as oseltamivir and ribavirin. The statin/caffeine combination also appeared to be more effective when administered preventatively rather than as treatment. These findings provide justification for further research into this novel antiviral formulation.