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DOI 10.1093/neuonc/noaf177

Медицинская библиотека · Neuro-oncology · 2025

Glioblastoma in adults: A Society for Neuro-Oncology (SNO) and European Society of Neuro-Oncology (EANO) consensus review on current management and future directions.

Wen Patrick Y, Weller Michael, Lee Eudocia Q, Touat Mehdi, Khasraw Mustafa, Rahman Rifaquat, Platten Michael, Lim Michael, Winkler Frank, Horbinski Craig, Verhaak Roel G W, Huang Raymond Y, Ahluwalia Manmeet S, Albert Nathalie L, Tonn Joerg-Christian, Schiff David, Barnholtz-Sloan Jill S, Ostrom Quinn, Aldape Kenneth D, Batchelor Tracy T, Bindra Ranjit S, Chiocca E Antonio, Cloughesy Timothy F, DeGroot John F, French Pim, Galanis Evanthia, Galldiks Norbert, Gilbert Mark R, Hegi Monika E, Lassman Andrew B, Le Rhun Emilie, Mehta Minesh P, Mellinghoff Ingo K, Minniti Giuseppe, Roth Patrick, Sanson Marc, Taphoorn Andreas Martin J B, Weiss von Deimling Tobias, Wick Wolfgang, Zadeh Gelareh, Reardon David A, Chang Susan M, Short Susan C, van den Bent Martin J, Preusser Matthias

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Аннотация

Glioblastoma is the most common type of malignant primary brain tumor and a major cause of morbidity and mortality. In 2021, the World Health Organization updated the classification of Central Nervous System (CNS) tumors to restrict glioblastomas to isocitrate dehydrogenase-wildtype (IDHwt) tumors, improving understanding of the prognosis and optimal therapy for these tumors. This revision also enables more homogeneous populations of patients to be enrolled in clinical trials, facilitating the evaluation of novel therapies. In this updated consensus review from the Society for Neuro-Oncology (SNO) and the European Association of Neuro-Oncology (EANO), the current management of patients with glioblastoma is discussed. In addition, novel therapies such as immunotherapies, viral therapies, targeted molecular therapies, theranostics, and antibody-drug conjugates will be reviewed, as well as the current challenges and future directions for research.

Для цитирования: Wen Patrick Y, Weller Michael, Lee Eudocia Q, Touat Mehdi, Khasraw Mustafa, Rahman Rifaquat, Platten Michael, Lim Michael, Winkler Frank, Horbinski Craig, Verhaak Roel G W, Huang Raymond Y, Ahluwalia Manmeet S, Albert Nathalie L, Tonn Joerg-Christian, Schiff David, Barnholtz-Sloan Jill S, Ostrom Quinn, Aldape Kenneth D, Batchelor Tracy T, Bindra Ranjit S, Chiocca E Antonio, Cloughesy Timothy F, DeGroot John F, French Pim, Galanis Evanthia, Galldiks Norbert, Gilbert Mark R, Hegi Monika E, Lassman Andrew B, Le Rhun Emilie, Mehta Minesh P, Mellinghoff Ingo K, Minniti Giuseppe, Roth Patrick, Sanson Marc, Taphoorn Andreas Martin J B, Weiss von Deimling Tobias, Wick Wolfgang, Zadeh Gelareh, Reardon David A, Chang Susan M, Short Susan C, van den Bent Martin J, Preusser Matthias. Glioblastoma in adults: A Society for Neuro-Oncology (SNO) and European Society of Neuro-Oncology (EANO) consensus review on current management and future directions.. Neuro-oncology. 2025. DOI: 10.1093/neuonc/noaf177.

Предметные рубрики MeSH

AdultHumansBrain NeoplasmsDisease ManagementGlioblastomaMedical OncologySocieties, MedicalConsensus Statements as Topic
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