Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association · 2013
Antihyperglycemic activity of Caralluma tuberculata in streptozotocin-induced diabetic rats.
Сравнительное исследованиеСтатьяПоддержка исследования: вне правительства СШАНазвание и аннотация: Перевод в очереди
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Abdel-Sattar Essam A, Abdallah Hossam M, Khedr Alaa, Abdel-Naim Ashraf B, Shehata Ibrahim A
Аннотация
The current study aimed at evaluating the potential and mechanisms of the antidiabetic activity of the methanolic extract (ME) of Caralluma tuberculata as well as its chloroform (CF), n-butanol (BF) and the remaining water fractions (RFs) in streptozotocin-induced diabetic rats. The antidiabetic activity was evaluated through assessing fasting blood glucose (FBG), insulin levels, oral glucose tolerance test (OGTT), glucose utilization by isolated rat psoas muscle, gut glucose absorption and G-6-Pase activity in isolated rat liver microsomes. Both ME and RF showed the highest potency, where ME had superior activity. The mechanism underlying the observed antihyperglycemic activity of ME could be attributed, at least in part, to enhanced skeletal muscle utilization of glucose, inhibition of hepatic gluconeogenesis and stimulation of insulin secretion. ME was standardized through LC-MS analysis for its major pregnanes.
Предметные рубрики MeSH
AnimalsApocynaceaeDiabetes Mellitus, Type 2Disease Models, AnimalEthnopharmacologyGluconeogenesisGlucoseHypoglycemic AgentsInsulinInsulin SecretionInsulin-Secreting CellsIntestinal AbsorptionMaleMicrosomes, LiverPhytotherapyPlant Components, AerialPlant ExtractsPregnanesPsoas MusclesRatsRats, Sprague-DawleySaudi ArabiaSolvents