Xi bao yu fen zi mian yi xue za zhi = Chinese journal of cellular and molecular immunology · 2014
[Adenovirus-mediated interleukin-24 enhances the inhibitory effect of paclitaxel on the growth of lung cancer A549 cells].
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Xu Mingju, Li Minmin, Yang Jicheng, Guo Jinjin, Sun Wanbang
Аннотация
OBJECTIVE: To investigate the effect of adenovirus-mediated interleukin-24 (Ad-IL-24) combined with paclitaxel on the growth of human lung cancer A549 cells in vitro.
METHODS: A549 cells were treated with Ad-IL-24 alone, paclitaxel alone and Ad-IL-24 combined with paclitaxel, respectively. Their proliferation was detected by CCK-8 assay, and the changes of apoptosis and cell cycle were tested by flow cytometry.
RESULTS: The treatment of Ad-IL-24 significantly inhibited the A549 cell growth and induced cell apoptosis. Compared with paclitaxel alone and Ad-IL-24 alone, the Ad-IL-24 plus paclitaxel treatment more evidently inhibited lung cancer cell growth and increased cell apoptosis rate, and induced G2/M phase arrest.
CONCLUSION: Ad-IL-24 infection can enhance the inhibitory effect of paclitaxel on lung cancer cell growth.
METHODS: A549 cells were treated with Ad-IL-24 alone, paclitaxel alone and Ad-IL-24 combined with paclitaxel, respectively. Their proliferation was detected by CCK-8 assay, and the changes of apoptosis and cell cycle were tested by flow cytometry.
RESULTS: The treatment of Ad-IL-24 significantly inhibited the A549 cell growth and induced cell apoptosis. Compared with paclitaxel alone and Ad-IL-24 alone, the Ad-IL-24 plus paclitaxel treatment more evidently inhibited lung cancer cell growth and increased cell apoptosis rate, and induced G2/M phase arrest.
CONCLUSION: Ad-IL-24 infection can enhance the inhibitory effect of paclitaxel on lung cancer cell growth.