Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026
World Trade Center neurotoxicant exposure severity is associated with cortical thinning and regional brain atrophy: a neuroimaging study of general responders at midlife.
СтатьяНазвание и аннотация: Перевод в очереди
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Clouston Sean A P, Huang Chuan, Askarov Temurbek, Wang Yicun, Chaudhry Zan, Carr Melissa A, Yang Yuan, West Steven, Mann Frank D, Marquez Ruth, Vaska Paul, Meliker Jaymie, Gandy Sam, Lucchini Roberto G, Luft Benjamin J, Alzheimer's Disease Neuroimaging Initiative
Аннотация
INTRODUCTION: Exposure to aerosolized pollutants is a risk factor for cognitive impairment and dementia, but the specific features of exposure-related neurodegeneration remain unclear.
METHODS: We measured the World Trade Center Neurotoxicant Exposure Severity Index (WTC-NESI) in 218 responders and unexposed controls aged 44-65 years. The main outcome was cortical thickness. Correlation analyses reported unadjusted associations and multiple linear regression to adjust for correlates. Vertex-wise analyses were used with threshold-free cluster enhancement to examine associations after adjusting for cross-vertex clustering in atrophy.
RESULTS: Cortical thickness was associated with WTC-NESI (R = -0.38, p < 0.001) that survived multivariable adjustment. Vertex-wise analyses revealed reduced cortical thickness across much of the cortical surface that was associated with WTC exposure severity. Results were right-hemisphere asymmetric and focused in the precentral regions (partial η2 ≥ 0.07).
CONCLUSION: Our results provide an important reference for neurotoxicological investigators mapping the implications of airborne pollutant exposures. This study suggests that efforts to mitigate exposures in first responders might have long-term implications for cerebral health.
METHODS: We measured the World Trade Center Neurotoxicant Exposure Severity Index (WTC-NESI) in 218 responders and unexposed controls aged 44-65 years. The main outcome was cortical thickness. Correlation analyses reported unadjusted associations and multiple linear regression to adjust for correlates. Vertex-wise analyses were used with threshold-free cluster enhancement to examine associations after adjusting for cross-vertex clustering in atrophy.
RESULTS: Cortical thickness was associated with WTC-NESI (R = -0.38, p < 0.001) that survived multivariable adjustment. Vertex-wise analyses revealed reduced cortical thickness across much of the cortical surface that was associated with WTC exposure severity. Results were right-hemisphere asymmetric and focused in the precentral regions (partial η2 ≥ 0.07).
CONCLUSION: Our results provide an important reference for neurotoxicological investigators mapping the implications of airborne pollutant exposures. This study suggests that efforts to mitigate exposures in first responders might have long-term implications for cerebral health.