Journal of chromatography. A · 2026
Review on isotachophoresis in trace biochemical sample analysis: state of art and future prospects.
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Mao Qi, Zhu Wangang, Luo Adam Ganxi, Yao Honghong, Han Bing, Gancheva Veska, Correia Jose Higino, Zhao Hong, Lin Zhiming, Li Zhecong, Hao Bohua, Lu Junyu, Huang Guangming, Xu Tao, Huang Liang, Hu Kui, Zhu Minjie, Ouyang Jingsong, Ferre Xavier Mateos, Karlsen Haakon, Sampietro Marco, Wang Zhuqing, Dong Tao
Аннотация
Isotachophoresis (ITP) is a green, efficient, and convenient technology for online sample purification and enrichment. Sample concentration is accomplished by leveraging differences in ion mobility within an electric field between the leading electrolyte and the trailing electrolyte. Over time, ITP devices have shown substantial improvements in sensitivity and detection limits for nucleic acid analysis. Additionally, the range of biological samples tested and disease-related applications has expanded considerably. This review principally emphasizes application progress of ITP in trace biochemical sample analysis especially nucleic acids. In particular, it provides an overview of common coupling techniques. Furthermore, the key parameters for ITP implementation in trace biochemical sample purification and enrichment are comprehensively summarized.