Impact of sterilization method on the system performance of lipid-based novel drug delivery.

Sterilization plays a crucial role in the safety and efficacy of lipid-based novel drug delivery systems (NDDS), particularly because of the high sensitivity of lipid components to various sterilization processes. This literature review investigates the impact of different sterilization methods, such as heat sterilization, filtration, radiation, as well as chemical and gas methods, on the physicochemical properties, stability, and therapeutic performance of lipid-based NDDS (LB-NDDS), including liposomes, microemulsions, nanoemulsions, solid lipid nanoparticles (SLN), and nanostructured lipid carriers (NLC). Special emphasis is placed on lipid degradation, drug content, and particle size alterations, that may occur during sterilization. Overall, understanding the suitable sterilization technique for LB-NDDS is critical for maintaining the integrity of drug delivery systems integrity and achieving optimal therapeutic outcomes. The findings provide a comprehensive analysis of the current challenges and recent advancement (supercritical CO2, electron beam, and ozone) of sterilization techniques that align with the sensitive nature of LB-NDDS.