Dental and medical problems · 2025
Challenges in defining an efficient cleansing protocol against mono- and multi-species biofilms on a cobalt-chromium alloy surface.
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Raile Priscilla Neves, Curylofo Patricia Almeida, Oliveira Viviane de Cássia, Macedo Ana Paula, Vasconcelos Glenda Lara Lopes, Paranhos Helena Freitas Oliveira, Pagnano Valéria Oliveira
Аннотация
BACKGROUND: Effective cleaning protocols are crucial for controlling biofilm formation on oral prostheses and preserving the oral health of patients relying on removable partial dentures (RPDs).
OBJECTIVES: The present study aimed to investigate the antibiofilm efficacy of 4 cleansing protocols on a cobalt-chromium (Co-Cr) alloy surface, which is commonly used as the base-metal framework material in dental prosthodontics.
MATERIAL AND METHODS: Cobalt-chromium specimens were contaminated with isolated strains of Candida albicans, Candida glabrata, Staphylococcus aureus, and Streptococcus mutans to form monospecies biofilms. For a multi-species biofilm, all strains were grown simultaneously on the surfaces of the specimens. After biofilm maturation, the specimens were immersed in different solutions: Ricinus communis 2%; R. communis 10%; Cepacol™; NitrAdine™; and distilled water (control). After applying the hygiene protocols, the viability of the microorganisms and the amount of residual biofilm were assessed..
RESULTS: Immersion in R. communis-based solutions did not significantly alter the viability of the microorganisms. Cepacol reduced the viability of C. albicans, C. glabrata and S. aureus in the mono-species biofilms, as well as C. glabrata in the multi-species biofilm. NitrAdine demonstrated effectiveness in reducing the viability of C. glabrata and S. mutans in both the monoand multi-species biofilms. However, its efficacy against S. aureus was only observed in the mono-species pattern. NitrAdine also reduced the area covered by the living biofilm.
CONCLUSIONS: The studied cleansing protocols exhibited reduced antimicrobial efficacy on the multispecies biofilm as compared to the mono-species model. NitrAdine showed potential as a complementary agent for controlling biofilm formation on removable partial dentures.
OBJECTIVES: The present study aimed to investigate the antibiofilm efficacy of 4 cleansing protocols on a cobalt-chromium (Co-Cr) alloy surface, which is commonly used as the base-metal framework material in dental prosthodontics.
MATERIAL AND METHODS: Cobalt-chromium specimens were contaminated with isolated strains of Candida albicans, Candida glabrata, Staphylococcus aureus, and Streptococcus mutans to form monospecies biofilms. For a multi-species biofilm, all strains were grown simultaneously on the surfaces of the specimens. After biofilm maturation, the specimens were immersed in different solutions: Ricinus communis 2%; R. communis 10%; Cepacol™; NitrAdine™; and distilled water (control). After applying the hygiene protocols, the viability of the microorganisms and the amount of residual biofilm were assessed..
RESULTS: Immersion in R. communis-based solutions did not significantly alter the viability of the microorganisms. Cepacol reduced the viability of C. albicans, C. glabrata and S. aureus in the mono-species biofilms, as well as C. glabrata in the multi-species biofilm. NitrAdine demonstrated effectiveness in reducing the viability of C. glabrata and S. mutans in both the monoand multi-species biofilms. However, its efficacy against S. aureus was only observed in the mono-species pattern. NitrAdine also reduced the area covered by the living biofilm.
CONCLUSIONS: The studied cleansing protocols exhibited reduced antimicrobial efficacy on the multispecies biofilm as compared to the mono-species model. NitrAdine showed potential as a complementary agent for controlling biofilm formation on removable partial dentures.