Ring chromosome 12 and severe oligospermia: a case report.

OBJECTIVE

To describe an unusual presentation of ring chromosome 12, which manifested as severe azoospermia, resulting in male infertility.

DESIGN

Case report.

SETTING

In vitro fertilization center at a tertiary care hospital.

PATIENT(S): A 27-year-old man diagnosed with unexplained azoospermia and ring chromosome 12 abnormality during a workup for primary infertility.

INTERVENTION(S): In vitro fertilization with preimplantation genetic diagnosis.

MAIN OUTCOME MEASURE(S): To confirm the importance of obtaining karyotypes in individuals with severe oligospermia.

RESULT(S): Full-term pregnancy after IVF using donor sperm.

CONCLUSION(S): Severe oligospermia and male infertility should be included in the spectrum of findings found in ring chromosome 12.