Fertility and sterility · 1996
Reinsemination of one-day-old oocytes by use of intracytoplasmic sperm injection.
Клиническое исследованиеСтатьяПоддержка исследования: вне правительства СШАНазвание и аннотация: Перевод в очереди
Обработка статьи · этапы, ошибки и управление
Загрузка состояния…
Ошибки и ограничения
История · было → стало
Состояние обновляется каждые 5 секунд, пока блок открыт. Процент показывается только там, где известен объём работы. Пауза останавливает продолжение этапа; текущий запрос к источнику может завершиться.
Lundin K, Sjögren A, Hamberger L
Аннотация
OBJECTIVE: To evaluate the possible advantages of reinseminating oocytes by use of intracytoplasmic sperm injection (ICSI).
DESIGN: Clinical study.
SETTING: In vitro fertilization unit with research facilities.
PATIENTS: Fifty-seven couples who were part of our regular IVF program.
INTERVENTIONS: Nonfertilized oocytes from IVF cycles with no or very low fertilization were microinjected with spermatozoa approximately 25 hours after oocyte pick-up.
MAIN OUTCOME MEASURES: Fertilization and pregnancy rates.
RESULTS: A mean fertilization rate of 46.5% was obtained when reinseminating the oocytes on day 2 using the ICSI procedure. Of 57 cycles with completely or almost completely failed fertilization, 29 patients received ET after reinsemination by ICSI. Two of these transfers resulted in pregnancies (6.9% per ET) and two healthy babies were born.
CONCLUSION: Despite this relative success, considering both the extra work involved and the potential genetic risk, it is doubtful whether ICSI on day 2 should be recommended as a routine procedure. For training and research purposes, however, this approach can be of value.
DESIGN: Clinical study.
SETTING: In vitro fertilization unit with research facilities.
PATIENTS: Fifty-seven couples who were part of our regular IVF program.
INTERVENTIONS: Nonfertilized oocytes from IVF cycles with no or very low fertilization were microinjected with spermatozoa approximately 25 hours after oocyte pick-up.
MAIN OUTCOME MEASURES: Fertilization and pregnancy rates.
RESULTS: A mean fertilization rate of 46.5% was obtained when reinseminating the oocytes on day 2 using the ICSI procedure. Of 57 cycles with completely or almost completely failed fertilization, 29 patients received ET after reinsemination by ICSI. Two of these transfers resulted in pregnancies (6.9% per ET) and two healthy babies were born.
CONCLUSION: Despite this relative success, considering both the extra work involved and the potential genetic risk, it is doubtful whether ICSI on day 2 should be recommended as a routine procedure. For training and research purposes, however, this approach can be of value.