Rice-memolin modulates prefrontal neural oscillations during sleep.

We investigated effects of rice-memolin on neural oscillations in the medial prefrontal cortex (mPFC) during sleep in mice. Spectral analysis revealed that rice-memolin treatment significantly attenuated theta power in the mPFC during rapid eye movement (REM) sleep. Furthermore, the power of beta and high gamma oscillations was significantly attenuated in the mPFC during non-REM sleep. Cardiac and autonomic functions remained unchanged. These findings suggest that rice-memolin modulates cortical network dynamics via specific oscillatory bands, potentially affecting local and global information processing underlying its procognitive properties.