Selenomethionine activates MAPK signaling to activate epidermal keratinocyte migration, speeding skin wound healing.

The skin, the body's biggest organ, is prone to persistent wounds when wound healing is impeded. Exploring safe and effective wound-healing drugs holds significant clinical importance. This study examined how selenomethionine (Se-Met) affects keratinocyte proliferation and migration using cell proliferation and scratch assays; an ICR mouse skin wound model was established to evaluate healing capacity and stained; and related gene activity was examined using RT-qPCR and Western blot. The results showed that Se-Met promoted the migration of HaCaT cells, regulated the MAPK pathway and MMP-2 and MMP-9 protein expression, improved wound healing rates in mice, enhanced tissue morphology, and decreased inflammatory markers like TNF-α, IL-6, and IL-1β's mRNA levels.